Hereditary thrombophilia. If you do, another blood test that examines your genes (called DNA) will be done to find out if Factor V Leiden is the cause of the resistance and what type of Factor V Leiden you have. Stand up and walk around during long flights. A genetic mutation (change) causes factor V Leiden. This disorder may raise your risk of a miscarriage or other complications. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Talk to your provider to see if you should be taking a blood thinner. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Medications can also work differently if they are taken on an empty stomach. 0000003297 00000 n Barbara Woodward Lips Patient Education Center. If you want to increase the amount you're eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. This is your bodys reaction to an injury that prevents you from bleeding too much. This means that for children with factor V Leiden, one out of 5,000-10,000 will get a blood clot. Advertising on our site helps support our mission. Although the prothrombin gene mutation is the second most common inherited predisposition to a deep vein thrombosis or pulmonary embolism, it is the weakest of all inherited clotting disorders in terms of risk of causing abnormal blood clots. A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. Factor V is a protein that is needed for blood to clot properly. Bauer KA. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Swelling in your leg or arm, which may appear suddenly. If you have an inactive (sedentary) lifestyle, consider how you could gradually increase your physical activity at home, school, work or play. If you are homozygous, you will pass the mutation on to your children. Rather, it's key to keep your intake of the nutrient consistent. Both men and women can have factor V Leiden. Soybean oil or soybean milk, as well as liver, has high vitamin K content, which may interfere with the action of VKAs. Read below where Experts have answered questions about Factor V Leiden. Pruthi RK (expert opinion). Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Factor V Leiden is the most common inherited condition causing increased blood clotting. This helps keep the blood flowing in your legs. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. Want to talk about Multiple Myeloma: Anyone else? Factor V Leiden is the name of one such blood clotting disorder. Calorie counting is not a feature of this diet plan. And it provides simple recipes that promise no more than 5 ingredients and 5 minutes of prep time. (accessed March 04, 2023). Your brothers and sisters may have inherited the mutated gene for Factor V Leiden, just like you did. If you have other chronic conditions such as diabetes, work with your health team to manage your health. Low-salt, low-fat: The plan is already geared toward low-fat and low-salt foods and may be adjusted further if needed. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. Up to 1 in 50 people who are Black, Hispanic or Native American. Farshchi, H. American Journal of Clinical Nutrition, January 2005. The Meat Effect: Protein, Carbs, and Your Diet. Depending on the severity of symptoms, other treatments may be necessary as well. Try to build up to 150 minutes of moderate-intensity. 3. The factor V Leiden mutation does not itself cause any symptoms. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. 0000001914 00000 n Most people with this disorder never develop a blood clot. If you get the mutation from both of your parents, you are homozygous (you have two abnormal copies of the Factor II gene). "Anticoagulant Food-Drug Interactions". Zoppi, Lois. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). The nutrient can interact with blood-thinning meds, but the idea is not to avoid foods high in vitamin K, like broccoli, kale, spinach and collard greens. Limitations: You can eat anything you want on your weekly cheat day." What can I do to support a healthy pregnancy? 0000007946 00000 n A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. Youll spend roughly the same amount on groceries if you keep the bulk of your protein purchases to eggs, lean meats and poultry, and fat-free dairy, as opposed to seafood. 0000003332 00000 n AHA: "Shaking the Salt Habit to Lower High Blood Pressure", Harvard T. H. Chan School of Public Health: "Vitamin K", AHA: "Understanding Your Risk for Excessive Blood Clotting", Using hormone therapy, including birth control pills, Immobility, either from lack of exercise, disability or sitting for long periods of time. Lockwood CJ, et al. Accessed June 4, 2018. The following supplements are theoretically capable of inhibiting VKAs, but their clinical effect is insignificant: Studies have shown that there is a 58% higher likelihood of achieving PT-INR values in the optimal therapeutic range of 2.0 to 3.0 if patients on VKA medication avoid herbal supplements or take them three or fewer times a week. 04 March 2023. Here's some information to help you prepare for your appointment. Wear compression stockings if your provider prescribes them for you. Or ask someone to drive you to the nearest emergency room. You inherit this condition from one of your biological parents. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. Do I need to limit my activity in any way? .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Some people do not have the normal Factor V protein. Signs of DVT: swelling or redness of your leg, with pain in your calf or inner thigh, Signs of PE: chest discomfort or shortness of breath. You won't go hungry on The 5-Factor Diet. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. If you are experiencing serious medical symptoms, please see the A. A blood test (called a screening test) can show if you have Activated Protein C resistance. Though scientific research on The 5-Factor Diet is lacking, the plan uses sound nutrition principles of healthy eating and weight loss. In 2010 I was pregnant with my son. In: Williams Hematology. Each part of the plan revolves around the number five. Women have a greater chance of developing a blood clot during pregnancy. The clot remains in place while other enzymes repair the damaged blood vessel. Laboratory testing (blood tests) diagnose this disorder. Accessed June 4, 2018. This happens because your body makes more of the Factor II (prothrombin) protein than you need for normal clot formation. A single copy of these materials may be reprinted for noncommercial personal use only. Keywords: papillophlebitis, factor v leiden, methylenetetrahydrofolate reductase mutation, retinal venous disease Introduction Papillophlebitis is a rare disease (higher prevalence in women of 20-35 years old), characterized by optic disc edema, retinal venous engorgement, and retinal hemorrhages, mainly located within the peripapillary area . Leg wraps that inflate and deflate to keep blood moving in your legs. 0000003221 00000 n Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. Zoppi, Lois. They may also suspect it if one or more of your biological family members have a history of blood clots. Cranberry products are not significant unless taken in high amounts, as for urinary infections. 2018;43 (5) (Specialty&Oncology suppl):12-15. Posted May 16, 2017 by Rachael 1000 Good Foods If you have been diagnosed with Factor V Leiden, you should alter your diet to prevent excessive blood clotting. I was diagnosed in 2001 after a series of TIA's and a smart neurologist who suspected there was something more to be investigated since I had a history of DVT's and my mother's family has had numerous blood clots. AskMayoExpert. (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). As a result, clotting goes on longer than usual. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. You may substitute gluten-free alternatives as long as they are low-sugar. Kaushansky K, et al., eds. Hereditary thrombophilia. It depends on the specific details of the previous deep vein thrombosis or pulmonary embolism. Are young and healthy when you get a clot. It is not a disease. News-Medical. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. If you have kidney disease, there may be too much protein in this diet for you. In heterozygous carriers of this mutation, the risk of developing a deep vein thrombosis or pulmonary embolism is about two to three in 1,000. Accessed June 4, 2018. Mayo Clinic is a not-for-profit organization. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. Counseling prior to taking birth control pills or before becoming pregnant. When the bleeding stops, different proteins tell the clotting factors to break apart so the clot can dissipate. Factor V Leiden follows an autosomal dominant inheritance pattern. Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. 4. Others can be life-threatening. If youre taking warfarin, youll need routine blood testing (prothrombin time test) to check how well your medication is working. %%EOF Adults need approximately 1 microgram/kg body weight of vitamin K a day. At least 1 of the genes that you inherited is the mutated gene that makes the Factor V Leiden protein. Cleveland Clinic is a non-profit academic medical center. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. 9th ed. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. Our mission of spreading lifesaving #bloodclot awareness is possible thanks to the generous support of our partners. Most notably, you will need to be aware of your vitamin K consumption. Youre might be wondering, Will this happen to me? 0000000016 00000 n As such, daily intake or extra supplementation with vitamin K is typically unnecessary to keep body stores at healthy levels. 1-ranked heart program in the United States. Serious illness, casts and surgery can increase your chances of developingblood clots. Yes, you can pass on the gene for this disorder to your children. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. Want to talk about Multiple Myeloma: Anyone else? However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . The two most common hematological diseases the impairment of Factor V causes are Factor V deficiency or Owren's disease, and Factor V Leiden. Accessed June 4, 2018. If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. Some people only need treatment for three months, but others will need blood thinner treatment indefinitely. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. Advertising revenue supports our not-for-profit mission. Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). 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Have had clots two or more different times in the past. Genetic and Rare Disease Information Center. Tenderness or pain in your leg or arm, which you may only feel when standing or moving around. Some people do not have the normal Factor V protein. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Symptoms may resolve within days or months, depending on the location and severity of your deep vein thrombosis or pulmonary embolism. Often, those treatments will require hospitalization. Low Vitamin K consumption if on Coumadin/Warfarin. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Cleveland Clinic is a non-profit academic medical center. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. Instead, they have an different form called Factor V Leiden. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. At this time, we cant treat or change our genes. As a result, your blood may clot more easily than it should, leading to serious complications. The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical. Factor V Leiden is a blood clotting disorder. with these terms and conditions. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially.